Comprehensive In Vitro Services
We offer a comprehensive set of in vitro services for assessing binding and potency of biotherapeutics.
15+ Years' Experience
We have over 15 years’ experience designing and performing binding and potency assays.
500+ Molecules
We have assessed more than 500 molecules.
Potency assessment
Potency assays are the foundation of understanding your therapeutic’s activity in order to inform the development program and manufacturing campaign.
Lonza can perform both safety and potency assays allowing for very early, cost effective assessments. Binding assays, for example ELISA can beperformed to verify target binding, especially useful following protein engineering, and we can go further with in vitro activity assays. Lonza can both source the cells for the assays as well as perform the assays which ensures an integrated supply chain.
Our in vitro potency assays
| Binding assays | Activity assays |
|---|---|
| ELISA binding assays | “True” potency assays (ADCC, ADCP, CDC) |
| Cell binding assays(membrane binding of the target cell) | General killing assays (eg.for ADCs) |
| Binding kinetics (Biacore, Octet) | Customized assays |
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